Synthesis, Characterization and Antibacterial Assessment of some Ni(II) and Cd(II) azomethine Complexes derived from 4 (2-aminoethyl) morpholine

Abstract

Azomethine complexes derived from 4 (2-aminoethyl) morpholine and their metal(II) complexes have been synthesized. The complexes were characterized by spectroscopic techniques and X-ray crystallography. The complexes were tested for antibacterial activity against selected nosocomial pathogens of Acinetobacter baumannii, Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa using the disc diffusion and broth micro-dilution. Overall results showed that the cadmium containing complex exhibited considerable antibacterial activities against Acinetobacte baumannii and MRSA. Results from the broth micro-dilution assay showed a much higher MIC value of the complex, ranging from 156.3 μg/mL to 625.0 μg/mL, when compared to the MIC value of antibiotics control of 2.0 μg/mL to 4.0 μg/mL. The in -vitro results indicate that metal complexes may be potentially utilized as an alternative to antibacterial drugs against nosocomial infections caused by both MRSA and A. baumannii.

Keywords: Azomethine; ccomplexes; nosocomial bacteria; antibacterial