Sythesis, Physico-Chemical and Antimicrobial Evaluation of Cu(II), Fe(II), Mn(II) Complexes with Schiff Base Derived from N-(2- hydroxybenzylidene)-3-(benzylideneamino)benzenesulfonamide

Abstract

A Schiff-base derived from N-(2-hydroxybenzylidene)-3-(benzylideneamino)benzene sulfonamide, and its metal complexes of Cu(II), Fe(II) and Mn(II) were synthesized and characterized based on their melting point decomposition temperature, solubility, molar conductance, magnetic moment and infrared analyses. Job’s method of continuous variation revealed that all the metal complexes are in 1:1 Metal-Ligand ratio. Physical and analytical data suggested that the Schiff base act as tretradentate ligand towards metal ion via azomethine-N, deprotonated phenolic-O and S=O group of sulphanilamine. All the complexes have low molar conductance value (11.28-66.8Ω^-1cm²mol^-1), indicating that they are non-electrolyte. The magnetic moment values ranges from1.74 to 5.98B.M shows that all the complexes are paramagnetic in nature. The synthesized ligand and its respective metal complexes were screened for their antibacterial activity against Staphylococcus aureus (Grampositive), Escherichia coli, (Gram-negative) bacterial strains and antifungal activity against Mucor inducus spp and Aspergillus fumigatus. The results of these studies revealed that the Schiff base and its metal complexes showed significant antibacterial and antifungal activity at high concentrations.