Synthesis, characterisation and antimicrobial studies on 2 - [(2 -hydroxyphenyl) methylidene] hydrazine-1-carbothioamide and its Ni(II) and Cu(II) complexes

Abstract

2-[(2-hydroxyphenyl)methylidene]hydrazine-1-carbothioamide was obtained by the condensation of salicyldehyde and thiosemicarbazone. Ni(II) and Cu(II) complexes were prepared and characterized by elemental (CHNOSO) analysis, FTIR, UV – visible, magnetic susceptibility, and molar conductance measurements. The ligand sharp peak at 1616cm^-1 in the FTIR spectra indicating the formation of azomethine (-C=N-) bond. A shift shows band to the band regions 1597cm^-1 and 1510cm^-1 confirmed the coordination of the azomethine nitrogen with Nickel(II) and Cu(II) ions respectively. The ligand formed a chelate with 1:2 metal : ligand stoichiometry. All the compounds have been screened for antibacterial and antifungal activity by disc diffusion method against Staphylococcus aureus, Escherichia coli and Salmonella typhi as well as Aspergillus flavus bacterial and fungal isolates respectively. The compounds are found to be active against the tested isolates.

Keywords: Schiff base, Chacterisation, Ligand, Antibacterial, Antifungal