Evaluation of Neutralizing Capacity of Different Commercial Brands of Antacid Tablets

Abstract

This study is based on the evaluation of acid neutralizing capacity of five different commercial brands of antacid tablets. Five different but widely used commercial antacid tablets were selected for the purpose of this study. Each of the sample tablets was purchased, crushed, weighed and kept at room temperature before being analyzed using titrimetric method. Titration of each sample tablet (0.5 g) dissolved in 20 cm³ of 0.1 M HCl with 0.1 M NaOH was carried out and the average titer values of different runs were recorded. The titre value for Gaviscon was 9.20 cm³, 13.04 cm³ for Gestid, 10.02 cm³ for Danacid, 10.10 cm³ for Cimetidine and 10.05 cm³ for Rennietidine. The neutralizing capacity (NC) of Gaviscon was found to be 82.6%, 53.4% for Gestid, 64.8% for Danacid, 49.8% for Cimetidine and 36.6% for Rennietidine. Analysis of the results shows that Gaviscon tablet has the highest NC, while Rennietidine shows lower NC value.

Keywords: Antacid, Neutralizing capacity, Titrimetric, Tablets, Ulcer