Screening of Cassia singuaena, Commiphora kerstingii, Khaya senegalensis for brine shrimp lethality and antiplasmodium activity

Abstract

Extracts of Cassia singueana, (twigs), Commiphora kerstingii (stem) and the bark of Khaya senegalensis were screened for antimalaria activity. Brine shrimp lethality assay was also employed as activity guide. Chloroform extracts of C. singueana was found to be the most active in both brine shrimp lethality (BST) and anti-malaria assay. The aqueous extract of K. senegalensis and Commiphora kerstinigii were found to be in-active against brine shrimp larvae. The phytochemical analysis of crude plants under investigation showed presence of saponins, tannins, glycosides and sterols.

Keywords: Screening of Cassia singueana, Commiphora kerstingii, Khaya senegalensis, brine shrimp test.