Synthesis, Characterization and Antibacterial Evaluations of the Schiff Base 2-(1-(2-(Piperazin-1-yl)ethylimino)ethyl)Phenol and its Complexes of Mn(II), Ni(II) and Zn(II)

Abstract

Schiff base 2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and its complexes of Mn(II), Ni(II) and Zn(II) were synthesized and characterized by molar conductance, FTIR, NMR, UV-Visible and elemental analysis. The complexes showed 1:1 metal to ligand (M:L) ratio according to the result obtained from Job’s method analysis. Elemental analysis and IR spectral data are in good agreement with the proposed structure of the ligand and the complexes. Both the ligand and its complexes were screened for in-vitro antibacterial activity against two gram negative (Escherichia coli and Klebsella) and two gram positive (Staphylococcus aureus and Streptococcus pyrogenes) bacterial strains. The result of antibacterial activity showed that both the ligand and its complexes have activity more than the referenced drug and that the complexes are more active than free ligand.

Keywords: Antibacterial studies, Characterization, Continuous variation, Synthesis