Antimicrobial Activity of 2-((2- Hydroxybenzylidene) Amino) Nicotinic Acid and Its Cobalt (II) Complexes Synthesized from OPhenylenediamine and 5-Nitrosalisaldehyde

Abstract

Compounds and Cobalt (II) complex of 2-{[(2-
hydroxyphenyl)methylidene]amino} nicotinic acid obtained from ophenylenediamine and 5-nitrosalicaldehyde were prepared and characterized using AAS, UV-Visible, IR, ¹HNMR, ¹³CNMR, and GCMS. The synthesized complex was screened against some microbes in order to establish its potential antimicrobial activity using some known drugs as references. The results obtained indicated that, the Schiff Base exhibited antimicrobial action against all the tested microbes except Candidas albicans isolate, which exhibited zero diameter zone of inhibition including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aeruginosa, and Proteus mirabilis. It was also found that the synthesized Schiff Base exhibited two digits purity range, implying that it was relatively stable. The biological activity of the metal complex of the Schiff Base was found to be comparably more suiting than that of the synthesized Schiff Base.