The resistance profile of some uropathogens in patients attending Obafemi Awolowo University Teaching Hospital for urological investigations

Abstract

Background: Urinary tract infections (UTI) are a common source of morbidity and mortality in all age groups in both sexes. Areas of concern in the treatment of UTI include the emergence of drug resistant uropathogens. Hence, the selection of drug resistant pathogens in both community acquired and nosocomial infections are of major concern world-wide.

Objective: This retrospective study was aimed at determining the sensitivity profile of some uropathogens to antibiotics in urological patients attending Obafemi Awolowo University Teaching Hospital located in Southwestern part of Nigeria.

Method: The microscopy, culture and sensitivity results of unselected mid stream urine specimens totaling 1015 received by the medical microbiology laboratory in the year 2000 were reviewed. Of these, 666 had all the information required for the study.

Results: The total number of isolates in this study was 430(64.6%) out of which Gram-negative bacilli accounted for 40.5 % . The largest of this group being Klebsiella 13.7%, others were Pseudomonas 11.1% and E.coli 8.3%. Gram positive isolates represented 11.6% of organisms cultured. S. aureus 9%, being predominant. C. albicans made up 0.9%.

Conclusion: There was a generally high level of resistance of isolates to beta lactams, macrolides, and amino glycoside antibiotics compared to the third generation cephalosporins and quinolone antibiotics. The paper also underscores the importance of filling out request forms properly.