Using control systems analysis and design concepts to understand hiv infection dynamics – a review

Abstract

This paper is a combination of some of our past and current works on the application of control theory to the study of HIV/AIDS. The paper aims to show how control theoretic analytical tools can be and have been applied to HIV/AIDS mathematical models in order to gain insights into HIV/AIDS infection dynamics. The paper presents works on viral load controllability, structured treatment interruption schedule design and identifiability of HIV/AIDS mathematical models. Results from related clinical trials are cited through out this paper in order to demonstrate how control theoretic and clinical studies can complement each other.

Keywords: HIV/AIDS mathematical models, control systems analysis, controllability, identifiability, structured treatment interruptions, biomedical engineering.