Isolation of Antibiotic Resistant Klebsiella pneumoniae from Students with UrinaryInfections at a Tertiary Institution, Southwest Nigeria

Abstract

The antibiotic resistance of urinary pathogens has been varying over the period of years, inhealthcare-associated infections. The study provided the current isolation of antibiotic resistant Klebsiella pneumoniae from students with UTI at a Tertiary Institution, Southwest  Nigeria. Inthe study, 200 clean midstream urine samples were collected and studied using standardmicrobiological techniques.  Information for the factors associated with UTIs was obtained using questionnaires. An agar disc diffusion technique was used to test for  antibiotic susceptibility. Thechi-square test was used to express associations among descriptive variables of UTI. The studyrevealed that  Klebsiella pneumoniae strains showed a low prevalence of UTI with 47(23.5%). The study showed females are more susceptible to UTIs  than males. The age-wise distributionshows that the incidence is more common in age bracket 21 to 30 years. The Klebsiella pneumoniae strains were most susceptible to imipenem 40(85.1%), meropenem33(70.2%), ceftazidime 32(68.1%), and cefexime 25(53.2%) as compare to amoxicillin-clavulanate43(91.5%), ampiclox 30(68.8%), cotrimoxazole 37(78.7%) and tetracycline 24(51.1%) withhighresistance rate. K. pneumoniae shown resistance to 9 different antibiotics with multipleantibiotic-resistance index of 0.6. Appropriate diagnosis and management of UTI are aimedat treating the acute occurrence as well as preventing recurrences of this infection.