The effect of corn cob on lipid profile of nickel induced heart toxicity in Wistar rats

Abstract

Background: Exposure to nickel produced physiological and biochemical disturbances in human and animals. Polysaccharides from corn cobs showed immunogenic, mitogenic, antioxidant and anti proliferative activities.
Aim: The aim of this study was to determine the effect of Corn Cob on lipid profile of nickel induced heart toxicity in wistar rats.
Methodology: Eighteen wistar rats were divided into six groups of three wistar rats each. The controls group were given 0.2mls of distilled water and rat diet and water adlibitum, rats in group 2 were administered with 0.5mg/kg Nickel, while rats in groups 3, 4 and 5 were administered with 0.5mg/kg Nickel with 300mg/kg, 450mg/kg and 600mg/kg of corn cob extracts respectively by oral intubation for 28 days. The Cholesterol, Triglycerides, High density lipoprotein (HDL), Low density lipoprotein (LDL) and Very Low density lipoprotein (VLDL) concentrations were estimated using standard methods. The data were analyzed using statistical package for social science (SPSS) version 25.
Results: There was significant difference (P<0.05) in LDL (Mmol/L) concentrations of 2.22+0.29, 3.32+0.19, 4.16+0.25, 2.09+0.27, 2.16+0.27 and 3.43+0.39 in control, Nickel treated, 300mg/kg, 450mg/kg, 600mg/kg and 450mg/kg Corn cob Ash respectively. There were significant difference (P<0.5) in Cholesterol concentration of Nickel and Nickel + 300mg/kg corn cob ash treated compared with the control. There were no significant difference (P>0.5) in HDL, Triglycerides and VLDL concentrations at different treatments compared with their respective controls.
Conclusion: The study showed that Nickel caused significant increase in Cholesterol and LDL. The administration of ash corn cob at 450mg/kg and 600mg/kg reversed the increased Cholesterol and LDL concentrations caused by Nickel.