Article Sidebar
Published:
Jul 18, 2024Keywords:
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Upon acceptance of a paper by the Journal, the author(s) have automatically transferred copyright of the paper to the BJMLS. The transfer will ensure widest possible dissemination of information.
Main Article Content
Zinc supplementation moderate body weight gain in night shift work and insufficient sleep models of chronic sleep deprivation
Abstract
Background: About 20 to 30 percent of employed adults are Sleep deprived in modern societies, either by extending working hours into the night as in Insufficient Sleep (IS) or works all through the night as in Night Shift Work (NSW). On the other hand, the increasing prevalence of overweight and obesity in these modern societies has been described as a global pandemic.
Aim: We therefore set up IS and NSW models of chronic sleep deprivation (SD) to study their effects on body weight and the role of concomitant Zinc supplementation on the SD induced body weight changes.
Methods: Forty adult male Wistar rats equally grouped into five; Control, NSW, NSWZ, IS and ISZ models. Each rat was given either 1 ml of distilled water (Control, NSW and IS models) or 5mg of Zinc sulfates (NSWZ and ISZ models) orally daily for 56 days of the study respectively. The NSW and NSWZ models were subjected to 12 hours of SD (07:00am – 07:00pm) while ISS and ISSZ models subjected to 18 hours of SD (07:00pm – 01:00pm next day) using improvised Modified Multiple Platform Method (MMPM). Biweekly body weight changes and serum Corticosterone were evaluated. Differences between models were examined with One-way ANOVA and Bonferonni’s post-hoc test. Statistical significance considered at p< 0.05.
Results: The NSW model recorded the highest percentage total body weight gain, while IS model recorded the highest serum corticosterone concentration. The SD models, most especially NSW incurred significant weight gain which may result to overweight and obesity, while Zinc supplementations significantly moderate the body weight changes.
Conclusion: The NSW and IS models of chronic SD induced increased body weight gain which was attributed to Hypothalamo-Pituitary-Adrenal axis activation, evidence by increase in serum corticosterone concentration. Concomitant Zinc supplementation significantly moderates chronic SD induced body weight gain.
