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Jul 18, 2024Keywords:
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Assessment of some inflammatory biomarkers in Plasmodium berghei infected mice treated with ethanol extract of Musa paradiaca
Abstract
Background: Musa paradisiaca possess certain medicinal properties as such have respective medicinal applications
Aim: The research aimed to assess the effect of a locally formulated herbal antimalarial therapy using dry plantain leaf extract (Musa paradisiaca) on some inflammatory biomarkers in mice infected with Plasmodium berghei
Methodology: Five groups of ten mice each namely control, P. berghei treated, artesunate treated P. berghei infected mice orally administered with curative, suppressive and prophylactic models 250, and 1000mg/kg Musa paradisiaca leaf extract for 5 days. Blood
smears were evaluated for parasitaemia on the 10th day and the mice sacrificed. The animals were sacrificed and serum obtained from blood samples collected through cardiac puncture was used for Xyclogenase, interleukin 6 and Lipogenase analysis using immuno assay methods. The data obtained from the experiment was analyzed using SPSS version 21.
Results: The Interleukine 6 (pg/ml) was 123.85±5.43, 817.40±6-01, 235.11±5.19, 287.35±0.48, 286.70±0.59, 247.07±0.59, 381.70±0.11, 394.07±0.11, 711.06±7.47, 776.12±0.96 and 672.21±5.87 in control, P.berghei, Artesunate, 250, 1000 mg Curative, Artesunate, 250 mg and 1000 mg Suppressive, 250 mg and 1000 mg prophylactic respectively. The Xyclogenase (µ/l) was 8.19±0.00, 26.64±5.8, 18.03±0.95, 5.05±0.21, 3.69±0.49, 13.93±1.72, 4.04±0.62, 1.68±0.37, 5.33±1.42, 2.44±0.02 and 3.24±0.05 in control, P.berghei, Artesunate, 250, 1000 mg Curative, Artesunate, 250 mg and 1000 mg Suppressive, 250 mg and 1000 mg prophylactic respectively. The Lipogenase (µ/L) was 7.56±0.38, 24.00±0.53, 12.48±1.67, 31.62±35.93, 7.69±0.53, 15.84±0.51, 13.45±0.49, 24.15±0.53, 21.20±0.69, 17.81±1.26 and 10.28±0.47 in control, P.berghei, Artesunate, 250, 1000 mg Curative, Artesunate, 250 mg and 1000 mg Suppressive, 250 mg and 1000 mg prophylactic respectively.
Conclusion: The study showed that ethanol leaf extract of Musa paradisiaca reversed the induction of inflammatory markers such as 1L-6, xylclogenase, and lipogenase that was induced by plasmodium berghie.
