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Jul 18, 2024Keywords:
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Effects of aqueous extract of Mangifera indica stem bark on cadmium induced renal damage in adult Wistar rats
Abstract
Background: Cadmium is one of the metallic substances that are not needed by the body but instead are very toxic to the body cells. Prolong .exposure to toxicant such as cadmium can lead to biochemical or pathological alterations in any organs of the body such as the kidney.
Aim: The aim of the study is to investigate the effects of aqueous extract of stem back of Mangifera indica extract on cadmium induced renal damage in adult Wistar rats.
Methodology: Thirty (30) adult Wistar rats were recruited for the study. They were randomly assigned into six (6) groups of five (5) animals each, Group A received food and water only, group B received 300mg/kg BW of aqueous stem bark of Mangifera indica group C received 1200mg/kg BW of aqueous stem bark of Mangifera indica, group D received 0.1ml/kg body weight of cadmium only, group E received 0.1ml/kg BW of cadmium + 300mg/kg BW of aqueous stem bark of Mangifera indica, group F received 0.1ml/kg BW of cadmium + 1200mg/kg BW of aqueous stem bark of Mangifera indica. Daily administration of Mangifera indica bark and cadmium were given through an orogastric tube for 30days.
Results: It showed that the orogastric administration of cadmium revealed significantly (p < 0.05) increased in the levels of urea and decreased in the levels of catalase (CAT) and superoxide dismutase (SOD) statistically. While, Mangifera indica groups at both high and low doses confirmed the reversal of these result to those comparable with the control. Histologically, group D showed focal tubular necrosis and heavy interstitial infiltrates of inflammatory cells. While the group that was given cadmium along with M. indica showed features of normal renal architecture at both lower and high dose.
Conclusion: It can be concluded that aqueous stem bark of Mangifera indica extract at both low and high dosage were able to ameliorate the renal tissue damage caused by cadmium on adult Wistar rats.
