Prognostic use of hormonal profile and bone markers in the assessment of menopausal and perimenopausal subjects at Lokoja International Market, Lokoja, Kogi State, Nigeria

Abstract

Background: Menopause is defined as the time in a woman’s life when menstrual cycle ends due to the natural depletion of ovarian  oocytes from aging and the deficiency of estrogen. It marks the end of fertility and it usually begins between ages 51 and 52, but can develop before or after this age. Menopause is diagnosed after 12 months of absence of menstruation.

Aim: This study aimed at  evaluating the Prognostic use of Hormonal profile and Bone Markers in the assessment of Menopausal and Perimenopausal Subjects at  Lokoja International Market, Lokoja, Kogi State, Nigeria.

Methodology: Participants aged between 16 and 65 years without any known  infertility challenges in their life were recruited for this study while women aged between 16 and 64years with previously known fertility  challenges were excluded from this study. All the hormones were measured using enzyme linked immunosorbent assay. Alkaline phosphatase, serum Calcium, and serum phosphorus were measured spectrophotometrically.

Results: There were significant correlation  between the hormonal profile and the bone markers amongst the study participants. The hormonal levels in menopausal and perimenopausal participants (groups A and B) were significantly different from hormonal levels of participants of women of reproductive  age (group C) (P≤0.05).

Conclusion: From the findings, the study thus conclude that hormonal profile and bone markers could be  significant markers for the assessment and monitoring of perimenopausal and menopausal symptom in patients.