In fructose induced metabolic syndrome in Wistar rats

Abstract

Background: Metabolic syndrome otherwise referred to as insulin resistance is defined as a cluster of conditions that raises the risk of cardiovascular disease, stroke and diabetes and is characterized by abdominal obesity, insulin resistance, hypertension, and dyslipidaemia.

Aim: The study was aimed at investigating the modulation of renal indices and nitric oxide synthase activity in fructose induced metabolic syndrome in Wistar rats.

Methods: Twenty (20) Wistar rats were randomly divided into 2 groups of 10 rats each: Group 1: test group treated with 10% fructose solution and Group 2: control received tap water. Baseline body weight, body mass index, fasting blood glucose, fasting lipid profile, urea, creatinine and nitric oxide synthase activity were measured using standard techniques. The rats were treated for 56 days and then final body weight and body mass index were taken after which the rats were anaesthetized and blood sample was obtained for biochemical analysis.

Results: The result from the study indicated that, there was a significant (p < 0.05) difference in body weight, fasting lipid profile, Urea, Creatinine and Nitric oxide synthase activities in treatment group compared with control group. The initial and final FBG concentrations in the test group was found to be significant (p<0.05). Also there was a significant difference between initial and final body mass index in the test group but not in control group. There was no significant difference between initial and final FBS concentrations in the control group.

Conclusion: the study provides evidence that 10% fructose administration caused increase in body weight, BMI, fasting blood sugar concentration dyslipidaemia, Urea, Creatinine activity and decrease activity of nitric oxide synthase

Keywords: Fructose; Metabolic syndrome; Nitric oxide synthase; Renal indices