Nano curcumin: A Review

Abstract

Background: Flavonoids' most important property is its antioxidant or radical scavenging ability, which protects cells from oxidative damage. Free radicals are rendered inactive
due to the strong reactivity of the hydroxyl group of flavonoids; instead, flavonoids are converted by radicals to less reactive radicals. Turmeric (Curcuma longa), is a cooking
spice used in Indian food and medicine, and encompasses cur cumin, which is a polyphenol and an active component. Cur cumin is a flavonoid found in the rhizome of the turmeric plant (Curcuma longa L.), and it has recently sparked interest of scientific researchers due to its wide range of biological and medicinal effects on chronic diseases including neurological disorders.
Aim: The goal of this review is to present a new current Nano biotechnological approach to disease treatment and the use of Nano cur cumin for disease management.
Methods: Cur cumin, a lipophilic polyphenol molecule produced from the rhizome of the turmeric plant, is currently widely regarded as one of the most promising anti-aging
treatment and other diseases available such as cancer and cardiac disease. Relevant research on neurodegenerative disease were found by searching PubMed, Web of Science,
Scopus, and the Cochrane Library databases.A total of 28 studies were included in the systematic review, which was based on a literature search.
Results: Cur cumin has antioxidant, immunomodulatory, anti-inflammatory, antimicrobial, cardio-protective, nephro-protective, hepato-protective, anti-neoplastic, antirheumatic,
and hypoglycaemic properties. Meanwhile Poor bioavailability due to hydrophobic characteristics, limited solubility and stability, and fast systemic clearance due to extensive intestine-liver metabolism are all significant challenges in its therapeutic utilization, however modern technologies in the field of Nano biotechnology investigations have been proposed in order to overcome this limitation.
Conclusion: Innovative Nano biotechnology techniques, such as Nano delivery-based strategies, are now being investigated to address current cur cumin bioavailability
limitations.