Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats

Abstract

The protective effects of Garcinia kola against a dose of Carbon-Tetrachloride (CC14)- induced liver damage in experimental rats were investigated. The CC14 induction (administered intraperitoneally, 0.5m1/kg body weight in olive oil-0.5ml/kg body weight) led
to significant increases in the levels of serum aspartate and alanine amino transferases, alkaline phosphatase and lipid peroxides in CC14 intoxicated rats. Pretreatment with varied concentrations of Garcinia kola diets (1%, 5% and 10%) and vitamin E (9%,) for 21 days prior to CC14 administration resulted in significant decreases in Liver marker enzymes and lipid peroxides. These findings suggest that Garcinia kola seed may be acting as a natural antioxidant that prevents hepatic oxidative stress induced by CC14