Changes in levels of serum beta-carotene, vitamin A and cholesterol in breast cancer of pre and post menopausal Nigerian women

Abstract

Twenty newly diagnosed breast cancer patients were assessed for serum vitamin A, β - carotene and total cholesterol levels with their matched control (n = 20). The mean age and standard deviation of pre-menopausal breast cancer patients was 34.75± 6.57 while the mean age and standard deviation for controls was 32.00 ±8.79 years. There was no statistical difference in age between the two groups (P< 0.05). There was evidence of decrease in the mean serum vitamin A with increasing stage of advanced breast cancer. However, the mean serum b-carotene level showed significant decrease in trend with increasing stage of advanced breast cancer (P< 0.05). Serum total cholesterol was negatively correlated with serum vitamin A but was found to be positively correlated though non-significantly with serum b-carotene in breast cancer patients and control (r = 0.10, p> 0.95 for cases; r = 0.05, p> 0.05 for control).

Keywords: β-carotene, vitamin A, breast cancer, menopause