Microwave-assisted synthesis and evaluation of antibacterial activity of 2,2'-(naph- thalene-2,7-diylbis(oxy))bis(N'-substituted acetohydrazide) derivatives

Abstract

A series of Schiff base of 2,2'-(naphthalene-2,7-diylbis(oxy))bis(N'-substituted acetohydrazide) (4a-m) derivatives has been synthesized by the acid catalyzed condensation of aryl/hetero aromatic aldehydes with 2,2'-(naphthalene-2,7-diylbis(oxy))diacetohydrazide (3) under microwave irradiation and conventional method for comparison. The structures of all the newly synthesized compounds have been characterized by IR, ¹H NMR, ¹³C NMR and Mass spectra. All the synthesized compounds have been screened for their in vitro antibacterial activity.

KEY WORDS: 2,2'-(Naphthalene-2,7-diylbis(oxy))diacetohydrazide, Schiff base, Microwave irradiation, Spectral characterization, Antibacterial activity

Bull. Chem. Soc. Ethiop. 2012, 26(2), 257-265.

DOI: http://dx.doi.org/10.4314/bcse.v26i2.9