One-pot three-component synthesis of 4-aryl-3,4-dihydro-pyrimidin-2(1H)-thiones catalyzed by Ni loaded SiO2

Abstract

A simple and efficient method has been developed for the synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-thiones from methyl 3-oxopentanoate, aldehydes and thiourea in the presence of a catalytic amount of Ni loaded SiO₂ at room temperature.

KEY WORDS: Ni loaded SiO₂, 4-Aryl-3,4-dihydropyrimidin-2(1H)-thiones, One-pot three-component synthesis, Methyl 3-oxopentanoate, Aldehydes,  Thiourea

Bull. Chem. Soc. Ethiop. 2012, 26(1), 121-126.

DOI: http://dx.doi.org/10.4314/bcse.v26i1.13