Mesoporous molecular sieve MCM-41 catalyzed one-pot synthesis of 3,4-dihydro-2(1H)-pyrimidinones and –thiones under solvent-free conditions

Abstract

An efficient synthesis of 3,4-dihydro-2(1H)-pyrimidinones and -thiones using MCM-41 as the catalyst from an aldehyde, β-keto ester, and urea or thiourea under solvent-free conditions is described.

KEY WORDS: Biginelli reaction, Dihydropyrimidinones, MCM-41, One-pot, Reusable

Bull. Chem. Soc. Ethiop. 2011, 25(2), 309-313.