N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin

Abstract

Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found.

KEY WORDS: L-like, Carbocyclic nucleosides, HBV

Bull. Chem. Soc. Ethiop. 2010, 24(3), 439-446.