A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

Abstract

A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K₂CO₃ is achieved in good yields.

KEY WORDS: 3-Cyano-2(1H)-pyridinones, 2-Imino, Cardiotonic, Dimethoxyacetophenone

Bull. Chem. Soc. Ethiop. 2010, 24(3), 433-438.