A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

Yahia Sh. Beheshtia; Maliheh Khorshidi; Majid M. Heravi; Bita Baghernejad

doi:10.4314/bcse.v24i3.60691

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DOI:

10.4314/bcse.v24i3.60691

Keywords:

3-Cyano-2(1H)-pyridinones 2-Imino Cardiotonic Dimethoxyacetophenone

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Vol. 24 No. 3 (2010)

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Articles

Yahia Sh. Beheshtia

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

Maliheh Khorshidi

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

Majid M. Heravi

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

Bita Baghernejad

Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran

Abstract

A highly efficient procedure for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres via a one-pot multicomponent reaction of 3,4-dimethoxyacetophenone, malonitrile or ethyl cyanoacetate, an aldehyde and ammonium acetate in the presence of K₂CO₃ is achieved in good yields.

KEY WORDS: 3-Cyano-2(1H)-pyridinones, 2-Imino, Cardiotonic, Dimethoxyacetophenone

Bull. Chem. Soc. Ethiop. 2010, 24(3), 433-438.

Bulletin of the Chemical Society of Ethiopia
Journal / Bulletin of the Chemical Society of Ethiopia / Vol. 24 No. 3 (2010) / Articles

DOI:

Keywords:

A catalytic method for the synthesis of 4-alkyl(aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents

Yahia Sh. Beheshtia

Maliheh Khorshidi

Majid M. Heravi

Bita Baghernejad

Abstract

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Yahia Sh. Beheshtia

Maliheh Khorshidi

Majid M. Heravi

Bita Baghernejad

Abstract

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