KSF-supported heteropoly acids catalyzed one-pot synthesis of α-aminonitriles

Abstract

In the presence of KSF-supported heteropoly acid as a heterogeneous, reusable and inexpensive catalyst, three-component reactions between aldehydes or ketones, amines, and trimethylsilyl cyanide preceded to afford α-aminonitriles in excellent yields, very short reaction times, and low loading of catalyst. This catalyst was highly selective and other functional groups including carbon-carbon double bond, and heterocyclic moieties did not affect the reaction.

KEY WORDS: Heterogeneous catalysis, Clays, Combinatorial chemistry, α-Aminonitrile, Heteropoly acid

Bull. Chem. Soc. Ethiop. 2010, 24(2), 209-215.