The anti-proliferative activities and morphological studies of 5,6-dihydrobenzo [d]thiazole derivatives synthesized from cyclohexan-1,3-dione

Abstract

This study focused on the synthesis of various benzo[d]thiazole derivatives with different substituents, exploring their potential as anticancer agents. The key starting material was 2-amino-5,6-dihydrobenzo[d]thiazol-7(4H)-one (4), which was synthesized through the reaction of 2-bromocyclohexane-1,3-diketone with thiourea. Compound 4 was then used to create azine and azole derivatives based on the benzo[d]thiazole core structure. The cytotoxicity of all the synthesized compounds was evaluated against several cancer cell lines, with many demonstrating notable inhibitory activity. The compounds were tested for anti-proliferative effects on six different cancer cell lines, and the results indicated that both the heterocyclic structure and the nature of the substituent groups had a significant impact on their inhibitory potential.

KEY WORDS: Benzo[d]thiazole, Fused derivatives, Multi-component reactions, Cytotoxicity, Morphology

Bull. Chem. Soc. Ethiop. 2025, 39(5), 967-986.                                                             

DOI: https://dx.doi.org/10.4314/bcse.v39i5.12