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Turgenia latifolia (L.) Hoffm: Chemical profiling and antioxidant, anti-inflammatory, and anticancer activities


Khaled Aggoun
Brahim Harkati
Ibrahim Demirtaş
Adem Şevki
Duygu Aygüneş Jafari
Zeyad Adil Hameed
Hocine Laouer
Ayomide Victor Atoki
Abdelkrim Gouasmia
Maria Atanassova
Sabry M. Attia
Sheikh F. Ahmed
Mohammed Messaoudi

Abstract

Turgenia latifolia is a medicinal plant that has not been studied previously. This study explores the first determination of its chemical profile and biological activities. LC-ESI-MS/MS identified trans-ferulic acid as the main compound in the Et₂O extract (10.012 mg/g) and chlorogenic acid in the EtOAc and BuOH extracts (1.944 mg/g and 3.539 mg/g, respectively). All extracts exhibited greater reducing power than the standards. The BuOH extract excelled in DPPH and reducing power (IC50 = 70.09 µg/mL, A0.5 = 0.83 µg/mL), while the Et₂O extract excelled in o-phenanthroline (A0.5 = 6.34 µg/mL) and showed the highest UV-B protection (SPF = 35.18). The EtOAc and BuOH extracts surpassed acarbose in α-amylase inhibition. The EtOAc extract demonstrated superior inhibition of xanthine oxidase and α-glucosidase (IC50 = 195.18 and 432.42 µg/mL, respectively), while the BuOH extract notably inhibited tyrosinase (IC50 = 360.00 µg/mL) and showed potent protein denaturation inhibition (76.16%). The Et₂O extract exhibited significant cytotoxicity against breast cancer cells (IC50 = 63.85 and 28.37 µg/mL for MCF-7 and MDA-MB-231, respectively). These findings highlight the pharmacological potential of T. latifolia as a promising source of bioactive compounds for therapeutic applications.


KEY WORDS: Biological activities, Breast cancer, Enzyme, Turgenia latifolia, LC-ESI-MS/MS


Bull. Chem. Soc. Ethiop. 2025, 39(5), 937-953.                                            


DOI: https://dx.doi.org/10.4314/bcse.v39i5.10


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eISSN: 1726-801X
print ISSN: 1011-3924