Synthesizing, characterization of some metal ion complexes with new azo dye and studying antioxidant and anticancer (MCF-7)

Abstract

This new azo dye 7-(3-hydroxy-phenylazo)-quinoline-8-ol was subsequently used to prepare a series of complexes with the chlorides of Fe, Co, Zn, Ru, Rh and Cd. The compounds identified by ¹H and ¹³C-NMR, FT-IR, UV-Vis, mass spectroscopy, as well as TGA, DSC, and C.H.N., conductivity, magnetic susceptibility, metal and chlorine content. The results showed that the ligand behaves in a trigonal behavior, and that the complexes gave tetrahedral, except for Fe, Ru and Rh octahedral was given, that all of them are non-electrolytes. The effectiveness of both the compounds in inhibiting free radicals was evaluated by the ability to act as an antioxidant was measured using DPPH as a free radical and gallic acid as a standard substance, the IC₅₀ value was determined, because the ligand was found to have a higher ability to inhibit free radicals, and the ability to inhibit the complex varied according to the IC₅₀ value. Cobalt, zinc and ruthenium complexes were evaluated as anticancer agents breast cancer MCF-7 in five concentration, the results showed that the IC₅₀ value for Zn was 43.38 µg/mL, while the ruthenium complex gave 63.57, cobalt complex gave 93.84 µg/mL, meaning that the Zn-complex gave a higher inhibition value than Ru and Co.

KEY WORDS: Antioxidant, Azo dye complexes, 8-Hydroxyquinoline, Anticancer

Bull. Chem. Soc. Ethiop. 2025, 39(5), 859-875.                                                  

DOI: https://dx.doi.org/10.4314/bcse.v39i5.5