Synthesis of and characterization some platinum(IV) complexes derived from substituted imides and evaluation of their biological activity

Abstract

This research paper explores preparation of furanoanthracene-12,14-dione (1) via the addition of malic anhydride to anthracene. The resultant compound was treated with urea to form the imide derivative (2). Subsequently (2) was reacted with formaldehyde, leading to the substitution of the nitrogen-bound proton with a hydroxymethyl group, yielding hydroxymethyl pyrroloanthracene (3). In the following step, various substituted anilines were reacted with (3) in the presence of triethylamine through an SN2 reaction to replace the hydroxyl group and producing substituted amino methyl-epipyrroloanthracene derivatives (4-10). Three of these derivatives (4-6) were employed as a ligands to synthesize three complexes square planer platinum(IV). The result of conductivity measurement, magnetic and C.H.N. prove the synthesis of the platinum(IV) complexes. The biological activities of the synthesized compounds were evaluated against four bacterial strains. Additionally, (4-10) were subjected to molecular docking studies against the target protein Penicillin Binding Protein (PDB ID: 3vsl), with Penicillin G serving as the control.

KEYWORDS: Platinum complexes, Imides, Molecular docking, Biological activity.

Bull. Chem. Soc. Ethiop. 2025, 39(3), 459-472.                                                   

DOI: https://dx.doi.org/10.4314/bcse.v39i3.6