Complexes of the antibiotic drug succinylsulfathiazole with the La(III), Sm(III), and Tb(III) ions: Spectral characterizations, microscopic pictures, and thermal properties

Abstract

Reacting the antibiotic drug succinylsulfathiazole (abbreviated as SST) with the lanthanide metal ions La(III), Sm(III), and Tb(III) generated thermal stable metal-based complexes. The temperature of the reaction was 70 ^oC, at a pH of ~ 8.5, using stoichiometry of 2:1 (SST ligand to metal ion). Spectral and analytical characterizations of the SST metal-based complexes were obtained using ultraviolet/visible (UV-visible), Fourier-transform infrared (FT-IR) spectroscopies, X-ray diffractometry (XRD), and CHN elemental analysis. The microscopic pictures of the SST complexes were captured by a high-resolution scanning electron microscope with environmental mode (ESEM). Experimental data suggested that the general composition of La(III) complex is [La(SST)₂(H₂O)Cl].6H₂O with a gross formula of C₂₆H₃₈N₆O₁₇S₄ClLa, the general composition of Sm(III) complex is [Sm(SST)₂(H₂O)(NO₃)].5H₂O with a gross formula of C₂₆H₃₆N₇O19S₄Sm, whereas the general composition of Tb(III) complex is [Tb(SST)₂(H₂O)(NO₃)].4H₂O with a gross formula of C₂₆H₃₄N₇O₁₈S₄Tb. In the manufactured complexes, two deprotonated SST molecules were captured the La(III), Sm(III), and Tb(III) ions by their bidentate carboxylate groups (COO^-). The microscopic pictures clearly revealed different surface topography between SST metal-based complexes.

KEY WORDS: Succinylsulfathiazole, Lanthanides, SEM, Surface morphology, EDS profile

Bull. Chem. Soc. Ethiop. 2025, 39(2), 327-339.                                                               

DOI: https://dx.doi.org/10.4314/bcse.v39i2.11