Chemoselective metal free deallylation of α-allyl-phenyl-carboxylic esters under reduction condition

Abstract

A simple and efficient method for chemoselective deallylation of –COO-allyl group in presence of C-allyl group has been developed. C-allyl cleavage of α-methylene compounds was successfully completed by refluxing with excess sodium borohydride in methanol. The reagent's stability, ready availability and ease of handling encourage its usage for deallylation.                                                                         

KEY WORDS: C-allyl cleavage, Sodium borohydride, Chemoselectivity, Reduction

Bull. Chem. Soc. Ethiop. 2025, 39(1), 131-139.                                                         

DOI: https://dx.doi.org/10.4314/bcse.v39i1.11