Synthesis, characterization, and antioxidant activity of novel diorganotin(IV) complexes derived from Ibuprofen-5-aminosalicylic acid ligand

Abstract

This study focuses on the preparations of a new ligand prepared by the condensation reaction between two substances ibuprofen and 5-aminosalicylic acid, and complexes of di organotin(IV) salts were prepared using this produced ligand to yield the appropriate complexes. The generated compounds were identified using FTIR and elemental analysis, in addition (tin, proton and carbon) magnetic resonance (¹¹⁹Sn, ¹H, and ¹³C, NMR). Octahedral geometry was suggested for the synthesized complexes based on the observations of the spectra. Two techniques were used to examine the antioxidant activity of the compounds: DPPH and CUPRAC. Because the tin element was present, the resultant complexes exhibited a higher rate of inhibition than the ligand. Di-methyltin-di-IAS also showed a greater effect as antioxidants than the other compounds.

KEY WORDS: Diorganotin(IV), Antioxidant activity, Ligand (IAS), DPPH method, CUPRAC method

Bull. Chem. Soc. Ethiop. 2025, 39(1), 101-110.                                                          

DOI: https://dx.doi.org/10.4314/bcse.v39i1.8