Synthesis of substituted 2-amino oxazoles with their cobalt(II) and platinum(IV) complexes and evaluation of their biological activity

Abstract

Many applications of green synthesis in the field of environment and biomedicine aiming at
decreasing the use of toxic chemicals through utilizing of plants which are safe. In this study, at 0.1 M concentration
of copper sulfate (CuSO4.5H2O), CuNPs were prepared and identified by changing the blue color into green color
(ethanolic extract) and from blue color to black color (water extract) and the spectrophotometric detection of
ultraviolet and infrared spectra. X-Ray diffraction (XRD) pattern was utilized to confirm the crystal structure of
CuNPs. The morphology and size of the CuNPs was measured by a high-resolution transmission electron
microscope (HR-TEM). Energy dispersive X-ray (EDX) was used for identification of the elemental composition
of CuNPs involving copper and oxygen. Field emission scanning electron microscopy (FESEM) was utilized to
confirm the shape of prepared copper nanoparticles. In vitro antibacterial activity was tested using two methods
including desk diffusion assay considering zones of inhibition and minimum inhibitory concentration (MIC) against
six types of certain bacterial types (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus
aureus, Streptococcus pneumoniae and Enterococcus faecalis). The results showed potent inhibitory activity of
copper nanoparticles (CuNPs) and water extract (Ext. 2) against all bacterial strains.

KEY WORDS: Copper nanoparticles, Piper Longum, Extract, Synthesis, Antibacterial

Bull. Chem. Soc. Ethiop. 2024, 38(6), 1667-1680.                                                           

DOI: https://dx.doi.org/10.4314/bcse.v38i6.13