Synthesis and in vitro screening of benzo[h]coumarinyl heterocycles as promising antibacterial agents

Abstract

In this study, benzo[h]coumarin and the corresponding substituted chalcones were designed and synthesized. These compounds have been used as a precursor to prepare various heterocyclic compounds like pyrimidines, pyrazole, pyrazole-1-carbothioamide, diazepines, oxazepines, isoxazoles and epoxides. The structures of the synthesized compounds were confirmed by FT-IR, ¹H and ¹³C-NMR spectroscopy. These target heterocyclic derivatives were biologically screened against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) pathogenic bacteria. The best obtained result was for compound (6b) against S. aureus, Gram-positive bacteria.

KEY WORDS: Benzo[h]coumarin, heterocyclic compounds, antibacterial activity

Bull. Chem. Soc. Ethiop. 2024, 38(6), 1815-1826.                                                   

DOI: https://dx.doi.org/10.4314/bcse.v38i6.24