Synthesis, spectroscopic characterization and antimicrobial evaluation of metal complexes with N-(2-aminophenyl)-4-(pentyloxy) benzamide compound ligand

Abstract

New metal complexes of Mn(II), Cu(II), Ni(II), Cd(II) and Zn(II) of (N-(2-aminophenyl)-4-(pentyloxy) benzamide were prepared and characterized, discovering new compounds with therapeutic value against microbial ligand and it's complexes were characterized using various analytical techniques. The electron spin resonance spectra of complex (4), [(L)(Cu)(OAc)₂(H₂O)₂].2H₂O, complex (5), [(L)(Cu)(Br)₂(H₂O)₂].2H₂O showed axial octahedral structure however complex (10) [(L)(Cu)(SO₄)(H₂O)₃].3H₂O showed compressed tetragonal geometry and complex (9) [(L)(Mn)(Cl)₂(H₂O)₂].H₂O showed isotropic type  the electronic spectra of copper(II) complexes (4), (5), (7) and (10) nearly showing bands at (240-270) nm, (300-380) nm, (420-573) nm and (610-770) nm ranges. For metal complexes, Mn(II) complex (2) is most sensitive complex against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas Aeruginosa, with 21, 25, 21, 22 mm, respectively inhibition zone whereas, Zn(II) complex (10) recorded the highest antimicrobial activity against Streptococcus aureus, The orders of the antimicrobial activity were Bacillus   subtilis: Standard drug ˃ Mn(II) complex (2) ˃ Zn (II) complex (11) ˃ Cd(II) complex (6) ˃ Cu(II) complex (5, 7) ˃ Cu(II) complex (4) ˃ Cu(II) complex (10) ˃ The ligand [L] (1) where the standard drugs were kanamycin (positive controls) and ampicillin (negative control).

KEY WORDS: Metals complexes, Spectra, Magnetism, Antibacterial activity, Ampicillin

Bull. Chem. Soc. Ethiop. 2024, 38(6), 1725-1742.                                                          

DOI: https://dx.doi.org/10.4314/bcse.v38i6.18