Synthesis, characterization and bioactive evaluation of cobalt(II) and copper(II) complexes of {4-[5-(5-sulfanylidene-2,5-dihydro-1H-1,2,4-triazol-3-yl) furan-2-yl] phenyl} acetic acid

Abstract

A new triazole derivative was synthesized by three steps. The first step involve adding 2-carboxyaledhyed furan to the 4-amino phenyl acetic acid after converting the substituted aromatic amine to the diazanium salt. In the first stage, [4-(5-formylfuran-2-yl) phenyl] acetic acid is the title of product. The second step is adding the thiosemicarbazide to the [4-(5-formylfuran-2-yl) phenyl] acetic acid which it gives the (4-{5-[(2-carbamothioylhydrazinylidene) methyl] furan-2-yl} phenyl) acetic acid. A final compound with the title {4-[5-(15-sulfanylidene-2,5-dihydro-1H-1,32,4-triazol-3-yl) furan-22-yl] phenyl} acetic acid was produced as a result of adding sodium acetate and chloro ethyl acetate to the product from the second step in the presence of triethyl amine which is used as a ligand to prepare cobalt(II) and copper(II) complexes. The structures of synthesized compounds were identified through the utilization of diverse measures, these measurements were (UV-Vis spectrum, LC-MS technique, FT-IR spectrophotometer, conductivity measurements, GC-mass spectra and atomic absorption) and melting point measurement. The results confirmed that the complexes have octahedral geometry. The biological activity data for the synthesized compounds revealed that the ligand and its complexes had antibacterial activity.

KEY WORDS: Synthesis, Triazole derivatives, Cobalt(II) complex, Copper(II) complex, Biological evaluation

Bull. Chem. Soc. Ethiop. 2024, 38(6), 1595-1607.                                                      

DOI: https://dx.doi.org/10.4314/bcse.v38i6.8