Antioxidant properties of triphenyltin(IV) complexes derived from a novel ibuprofen-5-aminosalicylic acid ligand: synthesis and characterization

Abstract

In this study, new ligand was prepared by condensation reaction between Ibuprofen and 5-amino salicylic acid (IAS), this prepared ligand was used to prepare three complexes of triorgnotin(IV) salts to obtain the corresponding complexes. The ligand (IAS) and complexes were characterized by several techniques such as infrared spectroscopy, (tin, proton and carbon) magnetic resonance (¹H, ¹³C, ¹¹⁹Sn NMR), elemental analyses. The antioxidant activity of the complexes was also studied. It was produced by two methods: DPPH and CUPRAC. The resulting complexes gave a higher rate of inhibition than the ligand due to the presence of the tin element in the complexes. Complex 1 (tri phenyltin-IAS) also shown greater antioxidant activity than the other compounds.

KEY WORDS: Ligand, Antioxidant activity, Triorganotin(IV), DPPH method, CUPRAC method

Bull. Chem. Soc. Ethiop. 2024, 38(5), 1329-1336.                                                   

DOI: https://dx.doi.org/10.4314/bcse.v38i5.11