Synthesis, evaluation, and structural characterization of antioxidant diorganotin(IV) Complexes derived from ampicillin: a comprehensive study

Abstract

This study offerings the preparation, structural analysis, and estimation of novel diorganotin(IV) complexes derived from an ampicillin as a ligand in terms of their antioxidant activity. The diorganotin complexes were yielded by a direct reaction between ampicillin and a different number of diorganotin(IV) chloride precursors. Various spectroscopic techniques, including CHNS, FTIR and nuclear magnetic resonance (¹H, ¹³C, ¹¹⁹Sn NMR), were used to explain the molecular structures of the produced complexes. Through in vitro experiments such as the CUPRAC and DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging technique, the novel diorganotin complexes' antioxidant activity were assessed. The results were compared to that of ligand antioxidants to evaluate the effectiveness of the complexes that were produced. The structural properties of the complexes were linked to their antioxidant capacity to identify the connection between molecular structure and biological function.

KEY WORDS: Ampicillin, DPPH method, Diorganotin(IV) complexes, Antioxidants

Bull. Chem. Soc. Ethiop. 2024, 38(5), 1291-1300.                                                           

DOI: https://dx.doi.org/10.4314/bcse.v38i5.8