Synthesis of substituted heterocyclic with their cobalt(Ⅱ) complexes from 2-amino- thiazoles and evaluation of their biological activity

Abstract

In this research, acetophenone and thiourea reacted in the presence of iodine to produce 2-amino-4-phenylthiazoles (1, 2). These compounds were then used in three different reactions to create substituted Schiff-bases (3-5) by further reactions with substituted benzaldehyde. To produce thiazole, they were first reacted with sodium azide (6). After adding maleic anhydride, they interacted with thioglycolic acid to yield oxazepine (7), and lastly, thiazolidine (8). The synthesised compounds (1-8) were confirmed to have their structures clarified by CHNS and spectroscopic methods such as infrared, ¹H NMR and ¹³C NMR. After being produced (1-4, 6-8), these compounds were used in 2:1 ratio reaction with CoCl₂.6H₂O to generate cobalt complexes (9-15). These complexes' magnetic characteristics, thermal analysis (TGA), and differential thermal analysis (DTA) were investigated. Several produced compounds were also tested against the growth of four different types of bacteria.

KEY WORDS: Schiff-bases, Thiazole, Oxazepine, Thiazolidine, Cobalt complexes

Bull. Chem. Soc. Ethiop. 2024, 38(4), 909-922.                                                

DOI: https://dx.doi.org/10.4314/bcse.v38i4.8