Design, synthesis of novel Schiff bases as potential insecticidal agents against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Abstract

In the present work, novel series of Schiff base 2-7 were synthesized via treatment of p-tosyloxy benzaldehyde with some indole and quinoxaline derivatives in ethanol under reflux. All product structures were verified using elemental analysis and spectroscopic investigations, including ¹³C NMR, ¹H NMR, and IR. Our research was conducted on the insecticidal activity, and biological effects of the recently synthesized Schiff bases on S. frugiperda. The results showed that compound 5 was the most active insecticide, nearly surpassing methomyl as a reference, with LC₅₀ values of 46.35 mg/L for second-instar larvae and 97.37 mg/L for fourth-instar larvae. This research opened up new avenues for the search for a novel class of insecticide.

KEY WORDS: Schiff bases, Spodoptera frugiperda, Insecticidal activity, Biological aspects, Toxicity

Bull. Chem. Soc. Ethiop. 2024, 38(3), 765-774.                                                              

DOI: https://dx.doi.org/10.4314/bcse.v38i3.17