Boosted antibacterial efficacy: Di and triorganotin complexes via 2-[(2,3-dimethylphenyl)amino]benzoic acid

Abstract

Using appropriate organotin chloride salts and a ligand called 2-[(2,3-dimethylphenyl) amino] benzoic acid (DMPAB), a condensation procedure produced novel complexes such as triphenyltin, dimethyl, diphenyl, and dibutyl-tin. For difficult identification, a variety of analytical methods were used, including elemental analysis, carbon and proton magnetic resonance, and infrared spectra. The agar ditch method was used to assess the antibacterial effectiveness against Staphylococcus aureus and Escherichia coli. When compared to the molecule generated from the ligand, the complexes showed more inhibitory action. Among the complexes tested, the dimethyltin carboxylate complex showed the strongest antibacterial action against Staphylococcus aureus and Escherichia coli.

KEY WORDS: Complexes, Antibacterial properties, Condensation process, Agar Ditch, Staphylococcus aureus and Escherichia coli

Bull. Chem. Soc. Ethiop. 2024, 38(3), 647-655.                                                            

DOI: https://dx.doi.org/10.4314/bcse.v38i3.8