Synthesis, spectral characterization, and biological activities of novel palladium(II) and platinum(II) complexes of active Schiff base ligands

Abstract

ABSTRACT. A new series of palladium(II) and platinum(II) Schiff base complexes have been synthesized by the interaction of ligands N-(2-fluoro benzylidene)isonicotinohydrazone (L¹H) and N-(2-fluorophenylethanone) isonicotinohydrazone (L²H) with PdCl₂ and PtCl₂. Elemental investigations, melting point determinations, molecular weight determinations, IR, ¹H NMR, and UV-Visible spectral studies were used to describe the structure and bonding pattern of ligands and their metal complexes. These analyses revealed that the ligands coordinate with the metal ions in a monobasic bidentate manner and that the complexes have a square planar geometry. The antimicrobial activities of both the ligands and their palladium(II) and platinum(II) complexes have been tested against various bacterial and fungal strains and showed considerable antifungal and antibacterial characteristics. The in vitro cytotoxic activity of [Pt(L²H)]Cl₂ complex was assessed by examining its potential to inhibit cell proliferation against the human HeLa cell line(cervical cancer cell line)  using MTT assay and the antioxidant activity of [Pt(L¹H)₂]Cl₂ compound was performed against DPPH. The results showed a dose-dependent cytotoxic and radical scavenging activity thus pointing towards the biological significance of Pt(II) complexes.

KEY WORDS: Schiff base ligands, Antimicrobial activity, Scavenging activity, Cytotoxic

Bull. Chem. Soc. Ethiop. 2023, 37(6), 1383-1396. 
DOI: https://dx.doi.org/10.4314/bcse.v37i6.7