Production rate of heterocyclic compounds iodinated N-(p-chlorophenyl)-3,5- dimethyl-1,1-dioxo-1,2-thiazine

Abstract

ABSTRACT. Iodinated heterocyclic molecules are crucial structural components of many natural products, including hormones, vitamins, and medicines. The pharmaceutical survey is very interested in the investigation of the kinetics of the iodination of N-(p-chlorophenyl)-3,5-dimethyl-1,1-dioxo-1,2-thiazine. The rate of iodination is directly dependent on the concentration of both 1,2-thiazine and iodine under different molar ratios (1:10), (10:1) adopted on the isolation method, the observed rate of iodination, the pseudo-first-order and the second order using (1:1) molar ratio in the overall reaction using spectrophotometric techniques. Thermodynamic activation parameters activation energy E_a, enthalpy change ΔH^#, entropy change ΔS^#, and Gibbs free energy ΔG^# of activation were calculated from the rate constant at temperatures 273, 283, 293, 303, and 318 K.

KEY WORDS: Production rate, 1,2-Thiazine, Iodine (I₂), Kinetic

Bull. Chem. Soc. Ethiop. 2023, 37(5), 1253-1262.                                                         

DOI: https://dx.doi.org/10.4314/bcse.v37i5.16