One-pot mediated synthesis of pyrimidine and quinazoline annulated derivatives of nitrogen containing five membered rings through their nitrile derivatives as antibacterial agents

Abstract

ABSTRACT. Novel five-membered ring (pyrrole, pyrazole and imidazole)-based pyrimidine and quinazoline derivatives were synthesized by one-pot domino approach. This approach has the advantages of high yield, mild reaction conditions and a simple work-up procedure. The structure of the synthesized compound was elucidated by spectroscopy technique and elemental analysis. The synthesized compound were examined for antimicrobial activity against four bacteria (E. coli, S. pyogenes, S. aureus, and P. aeruginosa) and two fungi (C. albicans and A. clavatus) and most of the synthesized compound exhibited moderate to good activity against reference drug ampicillin, ciprofloxacin, norfloxacin, gentamycin, nystatin and griseofulvin, respectively.

KEY WORDS: One-pot, Pyrrole, Pyrazole, Imidazole, Pyrimidine, Quinazoline, Antimicrobial activity

Bull. Chem. Soc. Ethiop. 2023, 37(5), 1193-1208.                                                          

DOI: https://dx.doi.org/10.4314/bcse.v37i5.12