Synthesis and characterization of inclusion complex of -cyclodextrin and triazole picrate

Abstract

ABSTRACT. Inclusion complex between 3-amino-1,2,4-triazole picrate and β-cyclodextrin was synthesized in order to increase the picrate solubility. The complex was obtained by co-precipitation method and its stoichiometry is 1:1 (guest–host). The structure of picrate and complex has been established by UV, X-ray diffractometry powder spectra, TGA, DSC, IR, ¹H NMR, and ¹³C NMR. The influence of the effect of pH on the complexation has been discussed. The value of apparent formation constant is 1.2 x 10⁴.

KEY WORDS: Amino triazole, Picrate, Inclusion complex, pH

Bull. Chem. Soc. Ethiop. 2023, 37(4), 973-982.                                                         

DOI: https://dx.doi.org/10.4314/bcse.v37i4.13