p-Anisidine release study by hydrolysis of Schiff bases in homogeneous media

Abstract

ABSTRACT. The objective of this work is to study the release of p-anisidine by the hydrolysis of synthesized Schiff bases N-vinylbenzylidene-p-anisidine (Im) as a monomer and its copolymers (Cp₁, Cp₂) with N,N-dimethylacrylamide (DMA). The hydrolysis behavior and kinetics are investigated in homogeneous media composed of ethanol/water (80% v/v) at 37 °C and at pH range of 4.0-10.0. The variation of the concentration over time is measured in thermostatically cells using UV-Vis spectroscopy. The results showed that the imine function hydrolysis obeyed to the first order for all compounds; the experimental kinetic constants are determined and the pH–rate diagram profile is established. It is noticed that the hydrolysis of imine function is extremely dependent on its carrier and the pH medium.

KEY WORDS: p-Anisidine, Copolymer, Schiff base, Hydrolysis, pH–rate diagram, Controlled release

Bull. Chem. Soc. Ethiop. 2023, 37(3), 745-755.                                                              

DOI: https://dx.doi.org/10.4314/bcse.v37i3.16