An investigation on fluorescence quenching of Cu(II) complex and in vitro cytotoxicity assay

Abstract

ABSTRACT. Fluorescence study of Cu(II) complex of 4-((2-hydroxynaphthalen-1-ylmethylene)amino)-N-(pyridin-2-yl)benzenesulfonamide by alizarin dye has been probed in DMSO. In the fluorescence quenching the electron transfer occurs from Cu(II) complex to alizarin. The structure of the complex was confirmed by EPR and powder XRD techniques. The Cu(II) complex has been amplified by in vitro antifungal minimum inhibitory concentration study and also has been submitted for in vitro cytotoxicity assay in  human cervical cancer cell line (He La). The biological study indicates that the [Cu(L₂)₂Cl₂] has significant antifungal and cytotoxic activity.

KEY WORDS: Cu(II) complex, Powder XRD, Fluorescence quenching, MIC study, In vitro cytotoxicity assay

Bull. Chem. Soc. Ethiop. 2022, 36(1), 25-32.                                                                    

DOI:   https://dx.doi.org/10.4314/bcse.v36i1.3