In situ acetonitrile/water mixed solvents: An ecofriendly synthesis and structure Explanations of Cu(II), Co(II), and Ni(II) complexes of thioxoimidazolidine

Abstract

ABSTRACT. The bidentate oxoacetate derivative of 4-oxo-2-thiazolidine 4ligand (L1) synthesized by the reaction of 1-(1-(Pyridin-3-yl)ethylideneamino)-2-thioxoimidazolidin-4-one 3 with diethyl oxalate with both traditional and microwave irradiation methods. The metal ion complexes of mixed ligands L1 and L2 (acetonitrile) were prepared by condensation a solution mixture of Co(II) Ni(II), and Cu(ІІ) metal chloride salts with the ligands (L1 and L2) in distilled water with stirring. The complexes were characterized by the micro analysis (C, H, N), chloride content, FT-IR, UV-Vis spectra, thermal gravimetric analysis (TGA), molar conductivity as well as magnetic susceptibility measurement. According to the obtained data the suggested coordination geometries of these complexes were suggested as octahedral structure. All the synthesized complexes were found to be electrolyte due to the presence of chloride ions outside the coordination sphere. The antibacterial activity of the L1 ligand and their metal ion complexes have been studied by screening against various microorganisms, G+ bacteria (Bacillus subtillis, Streptococcus pneumonia, and Staphyloccoccus aurease), G-bacteria (E. coli, and Pesudomonas Sp.) and fungi (Aspergillus nigaer, and Penicillium Sp.). The metal ion complexes gave the formulae: [M(L1)(L2)₂(H₂O)₂]Cl₂where M = Co(II) Ni(II), and Cu(ІІ).

KEY WORDS: Imidazolidine, Microwave irradiation, Transition metals complexes, Biological activity

Bull. Chem. Soc. Ethiop. 2021, 35(2), 351-364.

DOI: https://dx.doi.org/10.4314/bcse.v35i2.10