J. G. Tangmouo<sup>1</sup>
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
D. Lontsi<sup>1</sup>*
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
F. N. Ngounou<sup>1</sup>
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
V. Kuete<sup>2</sup>
<sup>2</sup>Department of Biochemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
A. L. Meli<sup>1</sup>
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
R. N. Manfouo<sup>1</sup>
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
H. Kamdem<sup>3</sup> W.
<sup>3</sup>Department of Chemistry, Faculty of Science, University of Dschang , P.O. Box 67, Dschang, Cameroon
P. Tane<sup>3</sup>
<sup>3</sup>Department of Chemistry, Faculty of Science, University of Dschang , P.O. Box 67, Dschang, Cameroon
V. Penlap Beng<sup>2</sup>
<sup>2</sup>Department of Biochemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
B. L. Sondengam<sup>1</sup>
<sup>1</sup>Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon
J. D. Connolly<sup>4</sup>
<sup>4</sup>Chemistry Department, University of Glasgow, G128QQ, Scotland, U.K.
Abstract
A new binaphthoquinone bearing two 4-hydroxy-5-methylcoumarin-3-yl units has been isolated from the stem bark of Diospyros canaliculata De Wildeman in addition to five known compounds: lupenone, betulinic acid, gerberinol, plumbagin and canaliculatin. Their structures were established on the basis of 1D (1H, 13C and DEPT) and 2D (1H-1H COSY, HMQC and HMBC) NMR experiments. Some of the above compounds showed a significant antimicrobial activity against bacteria and yeasts.
KEY WORDS: Diospyrone, Diospyros canaliculata, Ebenaceae, Bacteria, Yeasts
Bull. Chem. Soc. Ethiop. 2005, 19(1), 81-88
