Nicotine metal complexes: synthesis, characterization and bioactivities of some main group and some transition metals

Abstract

A number of some main group and transition metal nicotine complexes were synthesized and fully characterized using detailed structural and spectroscopic analysis techniques such as elemental analysis, molar conductivities, magnetic susceptibilities, IR, Raman and NMR techniques. Moreover, scanning electron micrographs and thermogravimetric analyses were also done. Cytotoxic activities of the binary nicotine metal complexes were tested and evaluated against HepG2 (human hepatocellular carcinoma), HPC3 (human prostate cancer), and HCT116 (human colorectal carcinoma) tumor cell lines. The antioxidant activities were examined by free radical scavenging assay. The antimicrobial activities of the synthesized complexes were evaluated against Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) microbes. The relationship between the chemical structure of the synthesized complexes and their biological influence as antimicrobial drugs was studied and evaluated.

KEY WORDS: Nicotine metal complexes, Cytotoxicity, Antioxidant, Antimicrobial

Bull. Chem. Soc. Ethiop. 2020, 34(3), 501-521.

DOI: https://dx.doi.org/10.4314/bcse.v34i3.7